Mega by B. L. Holmes

Kerek Leight, who is monitored by computer because of her past crimes of lesbianism and previous escape from the vast city-state of the Chicago-Milwaukee-Megalopolis, is approached by a group consisting of three scientists, a programer, a teacher and seven DNA-improved teens who have various psychic powers. The group wants Kerek to lead them in a new escape from the Mega's excessive social controls and its self-contained atmosphere. The seven psychics have predicted their freedom and it is soon revealed that they have been charged to perform a mysterious 'interlock' that will save the Earth from further destruction.
Unfortunately, Mega Central learns of their escape plan and is determined to stop them.